Studies on ablation efficiency with Hematoporphyrin Derivatives for atheromatous lesion

Myocardial lesion depth with circular electroporation ablation.

BACKGROUND Recently, we demonstrated the feasibility and safety of circular electroporation ablation in porcine pulmonary vein ostia, but the relationship between the magnitude of the application and lesion dimensions is still unknown. METHODS AND RESULTS An in vivo porcine study was performed on left ventricular epicardium submerged under 10 mm of blood, using devices that mimic a 20-mm-diam...

Biological studies on the main fractions of hematoporphyrin derivative.

The four main fractions of hematoporphyrin derivative were separated by high-pressure liquid chromatography. Each fraction was studied with respect to photosensitizing capabilities, fluorescence, and tumor tissue uptake in mice bearing EMT-6 tumors. Animals received i.p. injections of 10 mg/kg of each fraction, and 24 h later tumors either were treated with 100 J/cm2 of light (630 nm) to evalua...

Studies upon the Physiological Action of Hematoporphyrin

Studies upon the Physiological Action of Hematoporphyrin

THE RESULTS OF THESE OBSERVATIONS MAY BE BRIEFLY SUMMARIZED AS FOLLOWS: Feeding of hematoporphyrin to white mice over long periods of time produced no apparent changes in these animals and had no effect upon their sensitivity to light. Albino and slightly pigmented mice and rats injected with hematoporphyrin were protected from the rays of the sun by staining them a blue-black color with Verhoe...

Studies upon the Physiological Action of Hematoporphyrin